QianLab
Institute of Genetics and Developmental Biology
Chinese Academy of Sciences
 
 
 
 
Alumni
Teaching

~~Publications~~

   
 

 

(2014-)

(*, equal contributions; #, corresponding authors)

21. J. Zhou, X. Wang, M. Wang, Y. Chang, F. Zhang, Z. Ban, R. Tang, Q. Gan, S. Wu, Y. Guo, Q. Zhang, F. Wang, L. Zhao, Y. Jing , W. Qian , G. Wang, W. Guo# , C. Yang# (2018) The lysine catabolite saccharopine impairs development by disrupting mitochondrial homeostasis. The Journal of Cell Biology 218 (2): 580 (18 pages).[PDF]

20. C. Duan*, Q. Huan*, X. Chen*, S. Wu, L.B. Carey, X. He and W. Qian# (2018) Reduced intrinsic DNA curvature leads to increased mutation rate. Genome Biology 19(1):132 (12 pages).[PDF]

19. Q. Huan*, Y. Zhang*, S. Wu, and W. Qian# (2018) HeteroMeth: A Database of Cell-to-cell Heterogeneity in DNA Methylation. Genomics, Proteomics & Bioinformatics.16 (4), 234-243. [PDF]

18. Y.-F. Yang*, W. Cao*, S. Wu, and W. Qian# (2017) Genetic interaction network as an important determinant of gene order in genome evolution. Mol Biol Evol 34 (12), 3254-3266.[PDF]

17. Y. Han*, X. Chu*, H. Yu, Y.-K. Ma, X.-J. Wang, W. Qian#, and Y. Jiao# (2017) Single-cell transcriptome analysis reveals widespread monoallelic gene expression in individual rice mesophyll cells. Sci Bull 62 (19), 1304-1314. [PDF]

16. S. Chen, K. Li, W. Cao, J. Wang, T. Zhao, Q. Huan, Y.-F. Yang, S. Wu, and W. Qian# (2017) Codon-resolution analysis reveals a direct and context-dependent impact of individual synonymous mutations on mRNA level. Mol Biol Evol 34 (11), 2944-2958.[PDF]

15. Y.-F. Yang*, X. Zhang*, X. Ma*, T. Zhao*,Q. Sun, Q. Huan, S. Wu, Z. Du#, and W. Qian# (2017) Trans-splicing enhances translational efficiency in C. elegans. Genome Research. 27(9):1525-1535[PDF]

14. S. Wu*,# , K. Li*, Y. Li, T. Zhao, T. Li, Y.-F. Yang, W. Qian# (2017) Independent regulation of gene expression level and noise by histone modifications. PLoS Comput Biol 13 (6): e1005585. [PDF]

13. B. Zhang*, S. Wu*, Y. Zhang, T. Xu, F. Guo, H. Tang, X. Li, P. Wang, W. Qian, and Y. Xue (2016) A high temperature-dependent mitochondrial lipase EXTRA GLUME1 promotes floral phenotypic robustness against temperature fluctuation in rice (Oryza sativa L.). PLoS Genetics 12 (7): e1006152.[PDF]

12. C. Li, W. Qian, C. J. Maclean and J. Zhang (2016) The fitness landscape of a tRNA gene. Science 352 (6287): 837-40. [PDF]

11. W. Qian, and J. Zhang (2014) Genomic evidence for adaptation by gene duplication. Genome Research 24: 1356-1362. [PDF]

 

(2008-2012)

10. C. Park, W. Qian, and J. Zhang (2012) Genomic evidence for elevated mutation rates in highly expressed genes. EMBO Reports 13: 1123-1129. [PDF]

9. W. Qian, D. Ma, C. Xiao, Z. Wang, and J. Zhang (2012) The genomic landscape and evolutionary resolution of antagonistic pleiotropy in yeast. Cell Reports, 2: 1399-410. [PDF]

8. W. Qian, J.-R. Yang, N. M. Pearson, C. Maclean, and J. Zhang (2012) Balanced codon usage optimizes eukaryotic translational efficiency. PLoS Genetics 8 (3): e1002603. [PDF]

7. W. Qian, X. He, E. Chan, H. Xu, and J. Zhang (2011) Measuring the evolutionary rate of protein-protein interaction. Proc. Natl. Acad. Sci. USA 108: 8725-30. [PDF]

6. W. Qian*, B.-Y. Liao*, A. Y.-F. Chang, and J. Zhang (2010) Maintenance of duplicate genes and their functional redundancy by reduced expression. Trends in Genetics 26: 425-30. (*, equal contributions) [PDF]

5. X. He*, W. Qian*, Z. Wang*, Y. Li, and J. Zhang (2010) Prevalent positive epistasis in Escherichia coli and Saccharomyces cerevisiae metabolic networks. Nature Genetics 42: 272-6. (*, equal contributions) [PDF]

4. Z. Zhang, W. Qian, and J. Zhang (2009) Positive selection for elevated gene expression noise in yeast. Molecular Systems Biology 5: 299 (12 pages). [PDF]

3. W. Qian, and J. Zhang (2009) Protein subcellular relocalization in the evolution of yeast singleton and duplicate genes. Genome Biology and Evolution 1: 198-204. [PDF]

2. W. Qian, and J. Zhang (2008) Gene dosage and gene duplicability. Genetics 179: 2319-2324. [PDF]

1. W. Qian, and J. Zhang (2008) Evolutionary dynamics of nematode operons: easy come, slow go. Genome Research 18: 412-421. [PDF]

 


   
     
     
     
     
     
     
     
     
     
     
       
           
 

Lab phone: 010-64806548 Office phone: 010-64806550
Address: No.1 West Beichen Road, Chaoyang District, Beijing 100101,China