QianLab
Institute of Genetics and Developmental Biology
Chinese Academy of Sciences
 
 
 
 
Alumni
Teaching

~~Publications~~

   
 

 

(2014-)

(*, equal contributions; #, corresponding authors)

20. C. Duan*, Q. Huan*, X. Chen*, S. Wu, L.B. Carey, X. He and W. Qian# (2018) Reduced intrinsic DNA curvature leads to increased mutation rate. Genome Biology 19(1):132 (12 pages).[PDF]

19. Q. Huan*, Y. Zhang*, S. Wu, and W. Qian# (2018) HeteroMeth: A Database of Cell-to-cell Heterogeneity in DNA Methylation. Genomics, Proteomics & Bioinformatics.16 (4), 234-243. [PDF]

18. Y.-F. Yang*, W. Cao*, S. Wu, and W. Qian# (2017) Genetic interaction network as an important determinant of gene order in genome evolution. Mol Biol Evol 34 (12), 3254-3266.[PDF]

17. Y. Han*, X. Chu*, H. Yu, Y.-K. Ma, X.-J. Wang, W. Qian#, and Y. Jiao# (2017) Single-cell transcriptome analysis reveals widespread monoallelic gene expression in individual rice mesophyll cells. Sci Bull 62 (19), 1304-1314. [PDF]

16. S. Chen, K. Li, W. Cao, J. Wang, T. Zhao, Q. Huan, Y.-F. Yang, S. Wu, and W. Qian# (2017) Codon-resolution analysis reveals a direct and context-dependent impact of individual synonymous mutations on mRNA level. Mol Biol Evol 34 (11), 2944-2958.[PDF]

15. Y.-F. Yang*, X. Zhang*, X. Ma*, T. Zhao*,Q. Sun, Q. Huan, S. Wu, Z. Du#, and W. Qian# (2017) Trans-splicing enhances translational efficiency in C. elegans. Genome Research. 27(9):1525-1535[PDF]

14. S. Wu*,# , K. Li*, Y. Li, T. Zhao, T. Li, Y.-F. Yang, W. Qian# (2017) Independent regulation of gene expression level and noise by histone modifications. PLoS Comput Biol 13 (6): e1005585. [PDF]

13. B. Zhang*, S. Wu*, Y. Zhang, T. Xu, F. Guo, H. Tang, X. Li, P. Wang, W. Qian, and Y. Xue (2016) A high temperature-dependent mitochondrial lipase EXTRA GLUME1 promotes floral phenotypic robustness against temperature fluctuation in rice (Oryza sativa L.). PLoS Genetics 12 (7): e1006152.[PDF]

12. C. Li, W. Qian, C. J. Maclean and J. Zhang (2016) The fitness landscape of a tRNA gene. Science 352 (6287): 837-40. [PDF]

11. W. Qian, and J. Zhang (2014) Genomic evidence for adaptation by gene duplication. Genome Research 24: 1356-1362. [PDF]

 

(2008-2012)

10. C. Park, W. Qian, and J. Zhang (2012) Genomic evidence for elevated mutation rates in highly expressed genes. EMBO Reports 13: 1123-1129. [PDF]

9. W. Qian, D. Ma, C. Xiao, Z. Wang, and J. Zhang (2012) The genomic landscape and evolutionary resolution of antagonistic pleiotropy in yeast. Cell Reports, 2: 1399-410. [PDF]

8. W. Qian, J.-R. Yang, N. M. Pearson, C. Maclean, and J. Zhang (2012) Balanced codon usage optimizes eukaryotic translational efficiency. PLoS Genetics 8 (3): e1002603. [PDF]

7. W. Qian, X. He, E. Chan, H. Xu, and J. Zhang (2011) Measuring the evolutionary rate of protein-protein interaction. Proc. Natl. Acad. Sci. USA 108: 8725-30. [PDF]

6. W. Qian*, B.-Y. Liao*, A. Y.-F. Chang, and J. Zhang (2010) Maintenance of duplicate genes and their functional redundancy by reduced expression. Trends in Genetics 26: 425-30. (*, equal contributions) [PDF]

5. X. He*, W. Qian*, Z. Wang*, Y. Li, and J. Zhang (2010) Prevalent positive epistasis in Escherichia coli and Saccharomyces cerevisiae metabolic networks. Nature Genetics 42: 272-6. (*, equal contributions) [PDF]

4. Z. Zhang, W. Qian, and J. Zhang (2009) Positive selection for elevated gene expression noise in yeast. Molecular Systems Biology 5: 299 (12 pages). [PDF]

3. W. Qian, and J. Zhang (2009) Protein subcellular relocalization in the evolution of yeast singleton and duplicate genes. Genome Biology and Evolution 1: 198-204. [PDF]

2. W. Qian, and J. Zhang (2008) Gene dosage and gene duplicability. Genetics 179: 2319-2324. [PDF]

1. W. Qian, and J. Zhang (2008) Evolutionary dynamics of nematode operons: easy come, slow go. Genome Research 18: 412-421. [PDF]

 


   
     
     
     
     
     
     
     
     
     
     
       
           
 

Lab phone: 010-64806548 Office phone: 010-64806550
Address: No.1 West Beichen Road, Chaoyang District, Beijing 100101,China